94% vs 51%
The FDA had 74 antidepressant trials on file. In the journals, 94% looked positive. By the FDA's own count, 51% were. Twenty-two negative trials were never published; eleven were published as positive.

Kristy King, MD
A family doctor will find out with you. Eight women. Mauna Lani, Hawaiʻi. January 24 to 29, 2027.
Why I'm doing this
I've prescribed these. Then I read the trials nobody published.
94% vs 51%
The FDA had 74 antidepressant trials on file. In the journals, 94% looked positive. By the FDA's own count, 51% were. Twenty-two negative trials were never published; eleven were published as positive.
1.75 points
Across every trial submitted to the FDA from 1979 to 2016, 232 trials and 73,388 people, antidepressants beat placebo by 1.75 points on a 52-point scale. About 15% of people got a benefit beyond what placebo gave them.
No serotonin story
In 2022 a review of the major studies found no consistent evidence that depression is caused by low serotonin. What predicted depression was stressful life events.
1 in 7
About one in seven people who stop an antidepressant get withdrawal caused by the drug, and about one in 35 get severe symptoms. Most trials lasted eight weeks. 68% of people taking one have been on it for two years or more.
That is not a science. It is a market. The full record, with sources, is one page away. The rest of this site is what I'm building instead.
Kristy King, MD
Symbiotic Medicine
I'm not the same woman at 10 in the morning as I am at 3 in the morning. Neither are you. Your temperature, your heart rate, your hormones and your brain move on a daily clock. If you cycle, they move on a monthly one too, and across pregnancy and menopause on top of that. A living body is built to move. I'm a river. So are you.
Medicine built its idea of health on snapshots: one blood draw, one reference range, one trial average, one body on the textbook page. For most of the last century that body was a man, and women were kept out of the research for being "too variable." A snapshot cannot see a river move.
The heartbeat that never changes is the one in trouble.
In the Framingham study, every step down in heart rhythm variability carried a 70% higher risk of death within four years, independent of every usual risk factor. Variability is a vital sign.
Women were kept out of early drug trials from 1977 to 1993 for being "too variable."
When someone finally checked, across 311 studies, females were no more variable than males.
Becker, Prendergast and Liang, Biology of Sex Differences 2016.
Women make up 70% of reported cases of a dangerous heart rhythm triggered by heart medications.
A woman's electrical sensitivity to those drugs shifts across her cycle, and drug safety testing mostly ignores the cycle.
A healthy cycling woman's temperature moves half a degree and her resting pulse three to four beats every month.
That is enough for a wristband to find her fertile window. One visit's "normal" is a phase, not a person.
When Scottish hospitals adopted a woman's threshold for a heart attack blood test, five times as many women as men were newly found to have heart injury.
A year later those women were doing no better, because finding them changed nothing about how they were treated.
The average patient does not exist.
A person's own day-to-day variation is about eight times larger than the differences between people. A trial's average can describe nobody in it.
"Survival of the fittest" was Herbert Spencer's phrase, from 1864.
Darwin wrote that the communities with the most sympathetic members "would flourish best," and that neglecting the weak would mean "deterioration in the noblest part of our nature."
Spencer, Principles of Biology 1864; Darwin, The Descent of Man.
Among the Mosuo of China, women living in villages where land and family pass through women had half the odds of high blood pressure and a third the odds of chronic inflammation.
Women in patrilineal villages next door did not, and men showed no difference either way. Relationship is medicine.
Mechanism gets a citation. Every claim about how the body works carries a grade you can check.
History gets a document. Every claim about what was done to women carries the record.
The sacred gets my own voice. When I speak of source, of rhythm, of the shadow, I say it as mine, and I never dress it up as data.
I won't tell you cancer isn't real, that medicine never works, or that science is fake. I'll show you the record in plain language, and the decisions stay yours. I don't heal anyone. You do.
We read your terrain. Your nervous system, read electrically from your heart rhythm over three mornings and your heart rate and blood pressure lying and standing. What your cells are short of: omega-3 index, red cell magnesium, methylmalonic acid and homocysteine, ferritin, vitamin D. Your blood sugar, insulin, inflammation, thyroid and hormones. Your glyphosate level. A DNA test that shows how your body processes your medication. Then 90 minutes with Dr. King and a written Terrain Report in plain language that is yours to keep. $2,500, credited in full to the Week if you book within 90 days. Open to anyone, by telehealth in twelve states or in person on the Kohala Coast.
We repeat the heart rhythm, cell markers, glyphosate and questionnaires at the end of the Week and at 90 days, so you see your own before and after.
Eight women, Sunday night to Friday night at Mauna Lani. Your physiology measured before you arrive and again before you leave. Ninety days of care afterward. Four times a year. Founding price $8,900 for January 2027; lodging separate.
Ninety days of physician-led, slow, written medication reduction by telehealth, with visits every two weeks and messaging in between. $3,500. Every taper begins with a Terrain Assessment.
Flat fees. Lodging and travel separate. We bill no insurance and receive nothing from any hotel, laboratory or device maker.
The Electro-Equiscope is a microcurrent device listed with the FDA by its manufacturer. Listing is not FDA approval, and no device of this kind is cleared for any brain, mood or psychiatric use. It is used here for muscle and joint pain only.
Every tool earns its place against measurement, including the ones I like. No product sits at the center.
Is this still the right medication for my kid? Let's find out. A week together, teenager and one parent, with the medical work done before and after rather than during. First family week March 12 to 18, 2028.
Join the Families waitlistOne page, thirty rows, about a minute a day.
You will also hear from Dr. King now and then.